Organic and Biomolecular Chemistry p. 2584 - 2591 (2014)
Update date:2022-08-04
Topics:
James, Thomas
Maclellan, Paul
Burslem, George M.
Simpson, Iain
Grant, J. Andrew
Warriner, Stuart
Sridharan, Visuvanathar
Nelson, Adam
Piperazines are found widely in commercially-available compounds and bioactive molecules (including many drugs). However, in the vast majority of these molecules, the piperazine ring is isolated (i.e. not fused to another ring) and is not substituted on any of its carbon atoms. A modular synthetic approach is described in which combinations of cyclic sulfamidate and hydroxy sulfonamide building blocks may be converted into piperazines and related 1,4-diazepine and 1,5-diazocane scaffolds. By variation of the combinations of building blocks used, it was possible to vary the ring size, substitution and configuration of the resulting heterocyclic scaffolds. The approach was exemplified in the synthesis of a range of heterocyclic scaffolds that, on decoration, would target lead-like chemical space. It was demonstrated that lead-like small molecules based on these scaffolds would likely complement those found in large compound collections. This journal is the Partner Organisations 2014.
View MoreTaizhou Shengxing Chempharm Co.,Ltd
Contact:+86-576-88516600
Address:Yantou Chemical Zone Jiaojiang Taizhou Zhejiang China
Contact:+91 - 22 - 26355700
Address:17, Lotus Business Park, Andheri West
Shanghai Longjin Metallic Material Co., Ltd.
website:http://www.shlongjin.cn/
Contact:021-56517503,56502257
Address:No.16, Lane 555, Chengyin Road, Shanghai
LIANYUNGANG YC FINE CHEMICAL CO., LTD
Contact:+86-518-858 99188
Address:Shangdong Modern Bldg, South Greenpark Road, Lianyungang, Jiangsu Pro. China
website:http://www.greenutra.cn
Contact:0086-411-39553357
Address:No. 7-1-1802, Huizhi Garden,Ocean Square,Dalian, 116033, China
Doi:10.1016/S0040-4020(01)86985-4
(1994)Doi:10.1021/jm00051a008
(1994)Doi:10.1039/DT9940002645
(1994)Doi:10.1002/chem.201302761
(2014)Doi:10.1021/acs.orglett.8b01772
(2018)Doi:10.1021/jo00102a029
(1994)