Triazolinone Biphenylsulfonamide Derivatives as Orally Active Angiotensin II Antagonists with Potent AT1 Receptor Affinity and Enhanced AT2 Affinity

DOI: 10.1021/jm00043a020

Source and publish data:

Journal of Medicinal Chemistry p. 2808 - 2826 (1994)

Update date:2022-09-26

Topics:

Authors:

Ashton, Wallace T.

Chang, Linda L.

Flanagan, Kelly L.

Hutchins, Steven M.

Naylor, Elizabeth M.

et al. et al.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00043a020

Several series of 2,4-dihydro-2,4,5-trisubstituted-3H-1,2,4-triazol-3-ones with acidic sulfonamide replacements of tetrazole at the 2'-position of the biphenyl-4-ylmethyl side chain at N⁴ were prepared and tested as angiotensin II (AII) antagon

Full text of DOI:10.1021/jm00043a020

Products guided by the article

Product name:5-n-butyl-2-(2-chlorophenyl)-2,4-dihydro-4-[(2'-sulfamoylbiphenyl-4-yl)methyl]-3H-1,2,4-triazol-3-one

Cas No:159044-71-0

R&D Labs maybe for 159044-71-0

Shandong Jusage Technology Co.,Ltd.

Contact:86-13406130167

Address:No.20,North Ride No.9 Road, Guangrao Economic Development Zone, Shandong Province
Hangzhou Zyter Biological & Chemical Technology Co., Ltd.

website:http://www.zyterpharm.com

Contact:+86-18858184290

Address:West Wenyi Road, Cangqian, Yuhang
Xi'an caijing Opto-Electrical Science & Technology Co., LTD

Contact:+86-29-88294447

Address:NO.168 Zhangba Rd. East, Xi'an, P.R.China
Beijing Mesochem Technology Co.,LTD

website:http://www.mesochem.com

Contact:0086-10-57862036

Address:2301, Floor 23, Building 9 Lippo Plaza, Yard 8 Ronghua Middle Road, ETDZ, Beijing, China
Zhejiang Genebest Pharmaceutical Co.,Ltd.

Contact:0086-571-63532866

Address:No.1 Jinboshi Rd Lishan Town Fuyang City Zhejiang Province China

Relevant to this article

Contrasting free energies of electron transfer from [6] and [8]annulenes to their perdeuteriated-per-¹³C analogues

Doi:10.1016/S0040-4039(00)97011-4
(1990)
Synthesis of Amides and Esters by Palladium(0)-Catalyzed Carbonylative C(sp³)?H Activation

Doi:10.1002/anie.202007922
(2020)
Synthesis and Biological Evaluation of New Phthalazinone Derivatives as Anti-Inflammatory and Anti-Proliferative Agents

Doi:10.1002/ardp.201500336
(2016)
Synthesis and biological activities of some fluorine- and piperazine-containing 1,2,4-triazole thione derivatives

Doi:10.1016/j.cclet.2015.09.015
(2016)
Dual reactivity of O-α-allenyl esters under palladium(0) catalysis: From carbopalladation/allylic alkylation domino sequence to decarboxylative allenylation

Doi:10.1016/j.jorganchem.2012.03.014
(2012)
Atropisomerism about the C(1)-N single bond in N,N-disubstituted-1-aminoanthracenes: isolation of conformational diastereomers

Doi:10.1007/s12039-018-1473-9
(2018)

Article Doi