Triazolinone Biphenylsulfonamide Derivatives as Orally Active Angiotensin II Antagonists with Potent AT1 Receptor Affinity and Enhanced AT2 Affinity

DOI: 10.1021/jm00043a020

Source and publish data:

Journal of Medicinal Chemistry p. 2808 - 2826 (1994)

Update date:2022-09-26

Topics:

Authors:

Ashton, Wallace T.

Chang, Linda L.

Flanagan, Kelly L.

Hutchins, Steven M.

Naylor, Elizabeth M.

et al. et al.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00043a020

Several series of 2,4-dihydro-2,4,5-trisubstituted-3H-1,2,4-triazol-3-ones with acidic sulfonamide replacements of tetrazole at the 2'-position of the biphenyl-4-ylmethyl side chain at N⁴ were prepared and tested as angiotensin II (AII) antagon

Full text of DOI:10.1021/jm00043a020

Products guided by the article

Product name:5-n-butyl-2-(2-chlorophenyl)-2,4-dihydro-4-[(2'-sulfamoylbiphenyl-4-yl)methyl]-3H-1,2,4-triazol-3-one

Cas No:159044-71-0

R&D Labs maybe for 159044-71-0

LINAN HAIHUA CHEMICAL CO LTD

Contact:86-571-61063068

Address:LINAN
Shao Xing Empire Import&Export CO.,ltd

Contact:86-575-82127757

Address:11#, Weiwu Road, Shangyu Industrial Park, Hangzhou Bay, Hangzhou, Zhejiang Province, China
CHEM PLUS

Contact:0027-717-456976

Address:2ND FLOOR, 325 VAUSE ROAD, OVERPORT, 4001, SOUTH AFRICA
Chengdu Cogon Bio-tech Co., Ltd.

Contact:86-28-85171192

Address:NO.52.YongFeng Rd. Chengdu,610041,P.R.China.
Tianjin Crest Pharmaceutical R&D Co., Ltd. （Tianjin Yao Technology Development Co., Ltd.）(expird)

Contact:+86-22-66211386

Address:Building B5-405, No, 80 4th Avenue, TEDA, Tianjin, China P.R. 300457

Relevant to this article

Contrasting free energies of electron transfer from [6] and [8]annulenes to their perdeuteriated-per-¹³C analogues

Doi:10.1016/S0040-4039(00)97011-4
(1990)
Synthesis of Amides and Esters by Palladium(0)-Catalyzed Carbonylative C(sp³)?H Activation

Doi:10.1002/anie.202007922
(2020)
Synthesis and Biological Evaluation of New Phthalazinone Derivatives as Anti-Inflammatory and Anti-Proliferative Agents

Doi:10.1002/ardp.201500336
(2016)
Synthesis and biological activities of some fluorine- and piperazine-containing 1,2,4-triazole thione derivatives

Doi:10.1016/j.cclet.2015.09.015
(2016)
Dual reactivity of O-α-allenyl esters under palladium(0) catalysis: From carbopalladation/allylic alkylation domino sequence to decarboxylative allenylation

Doi:10.1016/j.jorganchem.2012.03.014
(2012)
Atropisomerism about the C(1)-N single bond in N,N-disubstituted-1-aminoanthracenes: isolation of conformational diastereomers

Doi:10.1007/s12039-018-1473-9
(2018)

Article Doi