Triazolinone Biphenylsulfonamide Derivatives as Orally Active Angiotensin II Antagonists with Potent AT1 Receptor Affinity and Enhanced AT2 Affinity

DOI: 10.1021/jm00043a020

Source and publish data:

Journal of Medicinal Chemistry p. 2808 - 2826 (1994)

Update date:2022-09-26

Topics:

Authors:

Ashton, Wallace T.

Chang, Linda L.

Flanagan, Kelly L.

Hutchins, Steven M.

Naylor, Elizabeth M.

et al. et al.

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Article abstract of DOI:10.1021/jm00043a020

Several series of 2,4-dihydro-2,4,5-trisubstituted-3H-1,2,4-triazol-3-ones with acidic sulfonamide replacements of tetrazole at the 2'-position of the biphenyl-4-ylmethyl side chain at N⁴ were prepared and tested as angiotensin II (AII) antagon

Full text of DOI:10.1021/jm00043a020

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Product name:5-n-butyl-2-(2-chlorophenyl)-2,4-dihydro-4-[(2'-sulfamoylbiphenyl-4-yl)methyl]-3H-1,2,4-triazol-3-one

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