E-64 analogs as inhibitors of cathepsin L and cathepsin S: Importance of the S2-P2 interactions for potency and selectivity

DOI: 10.1006/bioo.1994.1017

Source and publish data:

Bioorganic Chemistry p. 227 - 241 (1994)

Update date:2022-08-04

Topics:

Authors:

Gour-Salin

Goursalin

Lachance

Bonneau Bonneau

Storer Storer

Kirschke

Broemme Broemme

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Article abstract of DOI:10.1006/bioo.1994.1017

A number of epoxysuccinyl amino acid benzyl esters (HO-Eps-AA-OBzl, 1) in which the amino acid (AA) had been systematically varied were tested as inhibitors of cathepsins L and S. These E-64 analogs were designed to investigate whether selectivity for cat

Full text of DOI:10.1006/bioo.1994.1017

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