
Tetrahedron p. 11257 - 11266 (1994)
Update date:2022-07-30
Topics:
Atanes
Perez
Guitian
Castedo
Saa
N-protected 7-methyl-6a,7-dehydronoraporphines were synthesized by the intermolecular benzyne cycloaddition approach. During basic hydrolysis of the N-protecting group, oxidation of these compounds by oxygen led to guacoline and other 7-hydroxy-7-methyl-6,6a-dehydronoraporphines in what may be a biomimetic process.
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