New structural motifs for hammerhead ribozymes. Catalytic activity of abasic nucleotide substituted ribozymes

Article abstract of DOI:10.1080/15257779508012499

The synthesis of 1-deoxy-D-ribofuranose-3-(2-cyanoethyl N,N- diisopropylphosphoramidite) (6) from D-ribose and its incorporation into a hammerhead ribozyme is described.

Full text of DOI:10.1080/15257779508012499

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Nucleosides and Nucleotides
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New Structural Motifs for Hammerhead
Ribozymes. Catalytic Activity of Abasic
Nucleotide Substituted Ribozymes
Leonid Beigelman a , Alexander Karpeisky a , Jasenka Matulic-
Adamic a , Carolyn Gonzalez a & Nassim Usman a
a Departments of Chemistry & Biochemistry and Enzymology
Ribozyme Pharmaceuticals Inc. , 2950 Wilderness Place, Boulder,
CO, 80301, USA
Published online: 16 Feb 2007.
To cite this article: Leonid Beigelman , Alexander Karpeisky , Jasenka Matulic-Adamic , Carolyn
Gonzalez & Nassim Usman (1995) New Structural Motifs for Hammerhead Ribozymes. Catalytic
Activity of Abasic Nucleotide Substituted Ribozymes, Nucleosides and Nucleotides, 14:3-5, 907-910
To link to this article: http://dx.doi.org/10.1080/15257779508012499
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