Sulfonamide derivatives of benzylamine block cholesterol biosynthesis in HepG2 cells: A new type of potent squalene epoxidase inhibitors

DOI: 10.1016/S0960-894X(98)00213-3

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1337 - 1342 (1998)

Update date:2022-07-30

Topics: Sulfonamide Derivatives Benzylamine Cholesterol Biosynthesis HepG2 Cells

Authors:

Gotteland

Loubat Loubat

Planty Planty

Junquero

Delhon Delhon

Halazy Halazy

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(98)00213-3

Sulfonamide derivatives of ene-yne benzylamine 1 have been prepared and identified as a new class of potent SE inhibitors having demonstrated activity in HepG₂ cells as cholesterol biosynthesis inhibitors.

Full text of DOI:10.1016/S0960-894X(98)00213-3

Products guided by the article

Product name:(3-{[((E)-6,6-Dimethyl-hept-2-en-4-ynyl)-ethyl-amino]-methyl}-phenoxy)-acetonitrile

Cas No:159554-45-7

R&D Labs maybe for 159554-45-7

SHUNYUANSHENG BIO-PHARMTECH CO., LTD

website:https://www.whsysbio.com

Contact:--

Address:Building 13, Liandong U Valley-Wuhan Economic Innovation Valley, No. 259, Xingsan Road, Shamao Street, Hannan District, Wuhan City, Hubei Province
Afine Chemicals Limited

website:http://www.afinechem.com

Contact:+86-571-85134551

Address:No. 206 Zhen Hua Road, Hangzhou 310030, Zhejiang, China
Guangxi Bonger Pharmaceutical Co., Ltd

website:http://napo.lookchem.com/

Contact:+86-18817331185

Address:Donghai Industrial Zone, Tiandong Country,Guangxi,China
Chengdu D-Innovation Pharmaceutical Co., Ltd

Contact:86-28-85105536

Address:1001, B6, No.88 Keyuan South Road, Chengdu Hi-Tech Zone
Beijing Mediking Biopharm Co., Ltd.

Contact:+86-10-89753524/81760121/81769521

Address:Hongxianghong Incubator, Beiqijia Town, Changping district, Beijing, China

Relevant to this article

Peptide-based carbohydrate receptors

Doi:10.1002/chem.201303777
(2014)
Synthesis of quinazolinones from anthranilamides and aldehydes via metal-free aerobic oxidation in DMSO

Doi:10.1016/j.tetlet.2014.02.065
(2014)
Solution-processable highly efficient deep-red and orange organic light-emitting diodes based on multi-functional Ir(III) complexes

Doi:10.1039/c7tc02557b
(2017)
A Study of the Competition between the Di-?-methane and the Azadi-?-methane Processes in 2-Vinyl-β,γ-unsaturated Oxime Derivatives. The Novel Azadi-?-methane Reactivity of β,γ-Unsaturated Oximes

Doi:10.1021/jo00105a031
(1994)
Structure elucidation and total synthesis of kulkenon

Doi:10.1002/anie.201309386
(2014)
Diastereoselective propargylation of α-alkoxy aldehydes with propargyl bromide and zinc. A versatile and efficient method for the synthesis of chiral oxygenated acyclic natural products

Doi:10.1021/jo00115a049
(1995)

Article Doi