Sulfonamide derivatives of benzylamine block cholesterol biosynthesis in HepG2 cells: A new type of potent squalene epoxidase inhibitors

DOI: 10.1016/S0960-894X(98)00213-3

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1337 - 1342 (1998)

Update date:2022-07-30

Topics: Sulfonamide Derivatives Benzylamine Cholesterol Biosynthesis HepG2 Cells

Authors:

Gotteland

Loubat Loubat

Planty Planty

Junquero

Delhon Delhon

Halazy Halazy

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Article abstract of DOI:10.1016/S0960-894X(98)00213-3

Sulfonamide derivatives of ene-yne benzylamine 1 have been prepared and identified as a new class of potent SE inhibitors having demonstrated activity in HepG₂ cells as cholesterol biosynthesis inhibitors.

Full text of DOI:10.1016/S0960-894X(98)00213-3

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