Sulfonamide derivatives of benzylamine block cholesterol biosynthesis in HepG2 cells: A new type of potent squalene epoxidase inhibitors

DOI: 10.1016/S0960-894X(98)00213-3

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1337 - 1342 (1998)

Update date:2022-07-30

Topics: Sulfonamide Derivatives Benzylamine Cholesterol Biosynthesis HepG2 Cells

Authors:

Gotteland

Loubat Loubat

Planty Planty

Junquero

Delhon Delhon

Halazy Halazy

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(98)00213-3

Sulfonamide derivatives of ene-yne benzylamine 1 have been prepared and identified as a new class of potent SE inhibitors having demonstrated activity in HepG₂ cells as cholesterol biosynthesis inhibitors.

Full text of DOI:10.1016/S0960-894X(98)00213-3

Products guided by the article

Product name:(3-{[((E)-6,6-Dimethyl-hept-2-en-4-ynyl)-ethyl-amino]-methyl}-phenoxy)-acetonitrile

Cas No:159554-45-7

R&D Labs maybe for 159554-45-7

Linyi VIHO Chemical Co.,Ltd

Contact:86-15588110016

Address:LINYI CITY,SHANDONG PROVINCE,CHINA
hangzhou sunchem trading co., ltd.

Contact:13588470430--

Address:Room 406-407, the 4th Building, No549
ShangHai Ruiyi Medical Technology Co.,Ltd.

Contact:+86-21-54718086

Address:No951 Jianchuan RD，Minhang District
Wuhan Better Organic Technology Inc.

Contact:13307163183

Address:Wuhan Economic&Technology Development Zone, Hubei
feixia327@163.com

Contact:--

Address:80G, No.1 Building, Guodu Development Mansion, No. 182 Zhaohui Road, Hangzhou City, Zhejiang Province,China.

Relevant to this article

Peptide-based carbohydrate receptors

Doi:10.1002/chem.201303777
(2014)
Synthesis of quinazolinones from anthranilamides and aldehydes via metal-free aerobic oxidation in DMSO

Doi:10.1016/j.tetlet.2014.02.065
(2014)
Solution-processable highly efficient deep-red and orange organic light-emitting diodes based on multi-functional Ir(III) complexes

Doi:10.1039/c7tc02557b
(2017)
A Study of the Competition between the Di-?-methane and the Azadi-?-methane Processes in 2-Vinyl-β,γ-unsaturated Oxime Derivatives. The Novel Azadi-?-methane Reactivity of β,γ-Unsaturated Oximes

Doi:10.1021/jo00105a031
(1994)
Structure elucidation and total synthesis of kulkenon

Doi:10.1002/anie.201309386
(2014)
Diastereoselective propargylation of α-alkoxy aldehydes with propargyl bromide and zinc. A versatile and efficient method for the synthesis of chiral oxygenated acyclic natural products

Doi:10.1021/jo00115a049
(1995)

Article Doi