Sulfonamide derivatives of benzylamine block cholesterol biosynthesis in HepG2 cells: A new type of potent squalene epoxidase inhibitors

DOI: 10.1016/S0960-894X(98)00213-3

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1337 - 1342 (1998)

Update date:2022-07-30

Topics: Sulfonamide Derivatives Benzylamine Cholesterol Biosynthesis HepG2 Cells

Authors:

Gotteland

Loubat Loubat

Planty Planty

Junquero

Delhon Delhon

Halazy Halazy

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(98)00213-3

Sulfonamide derivatives of ene-yne benzylamine 1 have been prepared and identified as a new class of potent SE inhibitors having demonstrated activity in HepG₂ cells as cholesterol biosynthesis inhibitors.

Full text of DOI:10.1016/S0960-894X(98)00213-3

Products guided by the article

Product name:(3-{[((E)-6,6-Dimethyl-hept-2-en-4-ynyl)-ethyl-amino]-methyl}-phenoxy)-acetonitrile

Cas No:159554-45-7

R&D Labs maybe for 159554-45-7

SICHUAN TONGSHENG AMINOACID CO.LTD

website:http://www.aminoacid.cc

Contact:86-838-2274206/2850606

Address:Room 1-11-1,No.19 of North TianShan Road,Deyang,Sichuan China
Ji'an Hairui Natural Plant Co. Ltd.

Contact:0796-8105528

Address:Meilin industry park, Qingyuan district Ji'an City, Jiangxi Province
Wuhan Fortuna Chemical Co.,Ltd

website:http://www.fortunachem.com

Contact:86-27-59207850

Address:Add: Room 2015, No.2 Building, Kaixin Mansion No.107 Jinqiao Avenue, Wuhan, China
Jiangsu Zenji Pharmaceuticals LTD

Contact:+86-025-83172562; +1-224-888-1133(USA)

Address:No.5 Xinmofan Road
Shanghai shibo Chemical Co., Ltd

Contact:+86-021-60753516

Address:688 Qiushi Road, Jinshan High-tech Park, Shanghai, China,201512

Relevant to this article

Peptide-based carbohydrate receptors

Doi:10.1002/chem.201303777
(2014)
Synthesis of quinazolinones from anthranilamides and aldehydes via metal-free aerobic oxidation in DMSO

Doi:10.1016/j.tetlet.2014.02.065
(2014)
Solution-processable highly efficient deep-red and orange organic light-emitting diodes based on multi-functional Ir(III) complexes

Doi:10.1039/c7tc02557b
(2017)
A Study of the Competition between the Di-?-methane and the Azadi-?-methane Processes in 2-Vinyl-β,γ-unsaturated Oxime Derivatives. The Novel Azadi-?-methane Reactivity of β,γ-Unsaturated Oximes

Doi:10.1021/jo00105a031
(1994)
Structure elucidation and total synthesis of kulkenon

Doi:10.1002/anie.201309386
(2014)
Diastereoselective propargylation of α-alkoxy aldehydes with propargyl bromide and zinc. A versatile and efficient method for the synthesis of chiral oxygenated acyclic natural products

Doi:10.1021/jo00115a049
(1995)

Article Doi