I2/K2S2O8 Mediated Direct Oxidative Annulation of Alkylazaarenes with Amidines for the Synthesis of Substituted 1,3,5-Triazines

Article abstract of DOI:10.1002/ejoc.201901737

A direct method for the synthesis of heteroaryl-substituted 1,3,5-triazines from readily available methyl-azaarenes and amidines has been developed. The present method involves iodine mediated cascade aerobic C(sp³)–H oxidative amination and following condensation, cyclization with amidine. Both of methyl quinoline, pyridine and benzothiazole derivatives could be well tolerated to react with various amidines leading to corresponding products in good to excellent yields.