Design and Synthesis of a Conformationally Restricted Cysteine Protease Inhibitor

DOI: 10.1021/jo00104a022

Source and publish data:

Journal of Organic Chemistry p. 7671 - 7676 (1994)

Update date:2022-08-02

Topics:

Authors:

Cheng, Hengmiao

Keitz, Paul

Jones, J. Bryan

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jo00104a022

Using the X-ray analyses of papain and papain-chloromethyl ketone inhibitor complexes as representative cysteine protease structures, molecular graphics analyses were applied to design (4R,1'S)-2-<1'-<(benzyloxycarbonyl)amino>ethyl>-4-benzyl-4-<<(2-oxoeth

Full text of DOI:10.1021/jo00104a022

Products guided by the article

Product name:(2S,4R)-2-Phenyl-3-(carbobenzyloxy)-4-benzyl-4-<2-(methylsulfonyloxy)ethyl>oxazolidinone

Cas No:159801-67-9

R&D Labs maybe for 159801-67-9

Hangzhou GreenCo Science & Technology Co., Ltd.

Contact:86-571-88257303

Address:1713 Room,Jingui Building,Gudun Road,Xihu District,Hangzhou,China
Compro Shijiazhuang Fine Chemical Co., Ltd

Contact:0086-311-89689838

Address:Economic and Technological Development Zone of Shijiazhuang,Hebei
Wuhan Konberd Biotech Co., Ltd.

Contact:+86-27-87205925

Address:NO.666, Gaoxin Road, Eastlake High-tech zone
Shenzhen HwaGen Pharmaceutical Co., Ltd

website:http://www.rafflespt.com

Contact:+86-752-5538396

Address:Guangdong Huizhou China
Shenzhen ZheYi Chemicals Co.,LTD(Shanghai Branch)

Contact:+86-21-54159691

Address:Room1002,Building No.2, Lane 98 Bixiu Road,Minhang District, Shanghai,China 201100

Relevant to this article

Synthesis of novel [3,1]-benzothiazepine and [3,1]-benzoxazepine derivatives with antitumoral activity

Doi:10.1039/c3ra44937h
(2014)
A convergent synthesis of alkyne-azide cycloaddition derivatives of 4-α,β-2-propyne podophyllotoxin depicting potent cytotoxic activity

Doi:10.1016/j.ejmech.2014.02.030
(2014)
An efficient synthesis of highly substituted functionalized pyrroles via a four-component coupling reaction catalyzed by Fe(III)-Schiff base/SBA-15

Doi:10.1080/24701556.2020.1744650
(2020)
Total synthesis of panaginsene with structural revision

Doi:10.1021/ol500849m
(2014)
Polyoxometalate complexes for oxidative kinetic resolution of secondary alcohols: Unique effects of chiral environment, immobilization and aggregation

Doi:10.1039/c4dt00742e
(2014)
Enantioselective synthesis of α-amino acetals (aldehydes) via nucleophilic 1,2-addition to chiral 1,3-oxazolidines

Doi:10.1016/S0040-4039(00)78325-0
(1994)

Article Doi