Design and Synthesis of a Conformationally Restricted Cysteine Protease Inhibitor

DOI: 10.1021/jo00104a022

Source and publish data:

Journal of Organic Chemistry p. 7671 - 7676 (1994)

Update date:2022-08-02

Topics:

Authors:

Cheng, Hengmiao

Keitz, Paul

Jones, J. Bryan

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Article abstract of DOI:10.1021/jo00104a022

Using the X-ray analyses of papain and papain-chloromethyl ketone inhibitor complexes as representative cysteine protease structures, molecular graphics analyses were applied to design (4R,1'S)-2-<1'-<(benzyloxycarbonyl)amino>ethyl>-4-benzyl-4-<<(2-oxoeth

Full text of DOI:10.1021/jo00104a022

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