Design and Synthesis of a Conformationally Restricted Cysteine Protease Inhibitor

DOI: 10.1021/jo00104a022

Source and publish data:

Journal of Organic Chemistry p. 7671 - 7676 (1994)

Update date:2022-08-02

Topics:

Authors:

Cheng, Hengmiao

Keitz, Paul

Jones, J. Bryan

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jo00104a022

Using the X-ray analyses of papain and papain-chloromethyl ketone inhibitor complexes as representative cysteine protease structures, molecular graphics analyses were applied to design (4R,1'S)-2-<1'-<(benzyloxycarbonyl)amino>ethyl>-4-benzyl-4-<<(2-oxoeth

Full text of DOI:10.1021/jo00104a022

Products guided by the article

Product name:(2S,4R)-2-Phenyl-3-(carbobenzyloxy)-4-benzyl-4-<2-(methylsulfonyloxy)ethyl>oxazolidinone

Cas No:159801-67-9

R&D Labs maybe for 159801-67-9

ENERGYCO LTD.

Contact:+86-25-83719363

Address:106-7 Chunnan Rd, Chunxi Town, Gaochun, Nanjing, China
Changzhou Foreign Trade Corp

Contact:+86-519-86623222

Address:29F/D, 99 Yanling West Road, Changzhou, Jiangsu, China
Zibo Fuxi'er Chemical Co.,Ltd （Shanxian Fuxi'er Chemical Co.,Ltd）

Contact:+86-533-2091422

Address:Eastern 4 on the 3th Road ,Liangxiang Industrial Park, Zibo city ,Shandong,China
Zhengzhou Institute of Chiral Pharmer Research Co., Ltd.

Contact:86-371-55219111

Address:15 Floor, 2 Building, Central China Technovalley, Zhongyuan West Road
Triumph International Development Limilted

website:http://www.jiashengchem.cn/

Contact:+86-536-7971999

Address:Yinhai Road,Shouguang

Relevant to this article

Synthesis of novel [3,1]-benzothiazepine and [3,1]-benzoxazepine derivatives with antitumoral activity

Doi:10.1039/c3ra44937h
(2014)
A convergent synthesis of alkyne-azide cycloaddition derivatives of 4-α,β-2-propyne podophyllotoxin depicting potent cytotoxic activity

Doi:10.1016/j.ejmech.2014.02.030
(2014)
An efficient synthesis of highly substituted functionalized pyrroles via a four-component coupling reaction catalyzed by Fe(III)-Schiff base/SBA-15

Doi:10.1080/24701556.2020.1744650
(2020)
Total synthesis of panaginsene with structural revision

Doi:10.1021/ol500849m
(2014)
Polyoxometalate complexes for oxidative kinetic resolution of secondary alcohols: Unique effects of chiral environment, immobilization and aggregation

Doi:10.1039/c4dt00742e
(2014)
Enantioselective synthesis of α-amino acetals (aldehydes) via nucleophilic 1,2-addition to chiral 1,3-oxazolidines

Doi:10.1016/S0040-4039(00)78325-0
(1994)

Article Doi