Peptide bond formation via catalytic antibodies: Synthesis of a novel phosphonate diester hapten

Article abstract of DOI:10.1016/0040-4039(94)85022-4

Phosphonate diester 2, a hapten recently employed to induce the first monoclonal catalytic antibodies capable of catalyzing peptide bond formation, was synthesized via elaboration of scalemic α-amino phosphonate 4.