Synthesis of [1-[2',5'-bis-O-(t-butyldimethylsilyl)-β-L- ribofuranosyl]thymine]-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''- dioxide) (L-TSAO-T)

Article abstract of DOI:10.1080/15257779508012366

Derivatives of TSAO-T based upon pentofuranose sugars with the L- configuration have been prepared and evaluated as inhibitors of HIV-1 induced cytopathicity.

Full text of DOI:10.1080/15257779508012366

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Nucleosides and Nucleotides
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Synthesis of [1-[2′,5′-bis-O-(t-
Butyldimethylsilyl)-β- L-ribofuranosyl]
thymine]-3′-spiro-5″-(4″-amino-1″,2″-
oxathiole-2″,2″-dioxide) (L-TSAO-T)
Simon Ingate a , Ana San-Félix a , Erik De Clercq b , Jan Balzarini b
Maríia-José Camarasa a
&
a Instituto de Química Médica (C.S.I.C.), Juan de la Cierva , 3.
28006, Madrid, Spain
b Rega Institute for Medical Research, Katholieke Universiteit
Leuven , B-3000, Leuven, Belgium
Published online: 16 Feb 2007.
To cite this article: Simon Ingate , Ana San-Félix , Erik De Clercq , Jan Balzarini & Maríia-José
Camarasa (1995) Synthesis of [1-[2′,5′-bis-O-(t-Butyldimethylsilyl)-β- L-ribofuranosyl] thymine]-3′-
spiro-5″-(4″-amino-1″,2″-oxathiole-2″,2″-dioxide) (L-TSAO-T), Nucleosides and Nucleotides, 14:3-5,
299-301
To link to this article: http://dx.doi.org/10.1080/15257779508012366
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