Protecting group for carboxyl function: Mild and facile cleavage of 2- cyanoethyl ester under non-hydrolytic conditions

DOI: 10.1248/cpb.42.147

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 147 - 150 (1994)

Update date:2022-07-30

Topics:

Authors:

Kita Kita

Maeda Maeda

Takahashi

Fukui Fukui

Ogawa Ogawa

Hatayama

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Article abstract of DOI:10.1248/cpb.42.147

The use of the 2-cyanoethyl group for carboxyl-protection is described. This group was readily introduced by esterification using ethylene cyanohydrin and the deprotection was carried out under mild conditions using tetrabutylammonium fluoride in dimethylformamide-tetrahydrofuran.

Full text of DOI:10.1248/cpb.42.147

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