Synthesis of Functionalized Furopyridines via the Pd-catalyzed Coupling of Acetylenes to Iodopyridones. Preparation of a Key Intermediate to a New HIV Protease Inhibitor L-754,394.

Article abstract of DOI:10.1016/S0040-4039(00)78541-8

The synthesis of 1 was accomplished in 55percent overall yield via the Pd-catalyzed coupling of 3 and 4 followed by Cu-catalyzed cyclization of the resulting intermediate 2.