Synthesis and Biological Evaluation of 4-Deacetoxypaclitaxel

DOI: 10.1016/0040-4039(94)85019-4

Source and publish data:

Tetrahedron Letters p. 6843 - 6846 (1994)

Update date:2022-08-02

Topics:

Authors:

Chordia, Mahendra D.

Chaudhary, Ashok G.

Kingston, David G. I.

Jiang, Yuan Qing

Hamel, Ernest

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Article abstract of DOI:10.1016/0040-4039(94)85019-4

4-Deacetoxypaclitaxel (9) has been prepared in seven steps from paclitaxel (Taxol^<*>).It is significantly less active than paclitaxel in tubulin-assembly and cytotoxicity bioassays.

Full text of DOI:10.1016/0040-4039(94)85019-4

Products guided by the article

Product name:4-deacetyl-4-(S-methylxanthyl)-2'-tert-butyldimethylsilyl-7-triethylsilylpaclitaxel-1,2-carbonate

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