Synthesis, evaluation, and biological applications of visible-light-controllable nitric oxide releasers

Article abstract of DOI:10.1016/bs.mie.2020.04.002

Nitric oxide (NO) is biologically synthesized in human body and mediates various signal pathway. Because NO is too unstable to handle for biological assay, NO releasers had been developed for NO research. Among them, light-controllable NO releasers are quite useful tool because their NO release can be spatiotemporally controlled by light irradiation. This article shows how to synthesize visible-light controllable NO releasers based on N-nitrosoaminophenol structure, evaluate NO releasing efficiency in various methods, and apply them for biological experiments.