Conformationally restrained analogs of sympathomimetic catecholamines. Synthesis and adrenergic activity of tetrahydrobenzocycloheptene derivatives

DOI: 10.1016/0223-5234(94)90133-3

Source and publish data:

European Journal of Medicinal Chemistry p. 753 - 760 (1994)

Update date:2022-08-03

Topics:

Authors:

Macchia Macchia

Breschi Breschi

Gentili Gentili

Lapucci Lapucci

Macchia Macchia

Manera Manera

Martinelli

Martinotti

Nencetti

Nieri Nieri

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Article abstract of DOI:10.1016/0223-5234(94)90133-3

The tetrahydrobenzocycloheptene analogs 7-10 of norepinephrine (NE, 1) and isoproterenol (ISO, 2) were synthesized and tested for their α- and β-adrenergic properties by means of functional tests on isolated preparations. The conformational profile of 7 w

Full text of DOI:10.1016/0223-5234(94)90133-3

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Product name:1,2-dibenzyloxy-5-(aminomethyl)-6,7,8,9-tetrahydrobenzocyclohepten-5-ol

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