An Efficient Synthesis of Glycoprotein IIb/IIIa Inhibitor DMP728. A Novel Synthesis of Nα-Methylarginie-Containing Peptide

DOI: 10.1021/jo00109a027

Source and publish data:

Journal of Organic Chemistry p. 946 - 952 (1995)

Update date:2022-09-26

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Authors:

Xue, Chu-Biao

DeGrado, William F.

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Article abstract of DOI:10.1021/jo00109a027

An efficient synthesis of an antithrombotic cyclic peptide antagonist of glycoprotein IIb/IIIa, cyclo(D-Abu-N^α-methyl-Arg-Gly-Asp-m-(aminomethyl)benzoic acid) has been developed.In the course of this work an efficient and selective method has b

Full text of DOI:10.1021/jo00109a027

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