Design, synthesis and biological evaluation of benzylisoquinoline derivatives as multifunctional agents against Alzheimer's disease

DOI: 10.1016/j.bmcl.2014.03.058

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2368 - 2373 (2014)

Update date:2022-08-03

Topics:

Authors:

Xu, Zi-Chen

Wang, Xiao-Bing

Yu, Wen-Ying

Xie, Sai-Sai

Li, Su-Yi

Kong, Ling-Yi

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Article abstract of DOI:10.1016/j.bmcl.2014.03.058

A novel series of benzylisoquinoline derivatives were designed, synthesized, and evaluated as multifunctional agents against Alzheimer's disease (AD). The screening results showed that most of the compounds significantly inhibited cholinesterases (ChEs),

Full text of DOI:10.1016/j.bmcl.2014.03.058

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