Bioorganic and Medicinal Chemistry Letters p. 3039 - 3044 (1997)
Update date:2022-08-03
Topics:
Wattanasin, Sompong
Boettcher, Brian R.
Scallen, Terry
The squalene synthase inhibiting properties of farnesyl diphosphate (FPP) mimics, 3 and related analogues, are described. The results indicate that the nonphosphorus-containing N-hydroxyglycine is a novel replacement for the diphosphate group. Further optimization of 3 has led to 12, a new and potent squalene synthase inhibitor.
View MoreContact:+86-579-85206992
Address:No 451 chouzhou north road ,room 1106 int'l business center , yiwu ,china
Contact:18710867521(wechat)
Address:Rm10516,Galaxy Tech Building #2,No.25 Tangyan Rd,Hi-Tech Zone,Xi'an, China
website:http://www.sjc.com.tw
Contact:(886) 2-2396-6223
Address:14Fl., No. 99. Sec. 2, Jen Ai Road
Ji'nan Orgachem Pharmaceutical Co.,Ltd
Contact:+86-531-82687810
Address:Jinan
Hunan Shineway Enterprise Co., Ltd.
Contact:+86-731-86303875
Address:118, Huanghua International Airport Road, Huanghua Town, Changsha, Hunan 410137, China
Doi:10.1055/s-0036-1588138
(2017)Doi:10.1021/jo001485c
(2001)Doi:10.1016/S0040-4039(97)10733-X
(1998)Doi:10.1002/prac.19983400207
(1998)Doi:10.1007/s12039-016-1106-0
(2016)Doi:10.1021/jm970595h
(1998)
