N-Hydroxyglycine derivatives as novel inhibitors of squalene synthase

DOI: 10.1016/S0960-894X(97)10133-0

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 3039 - 3044 (1997)

Update date:2022-08-03

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Authors:

Wattanasin, Sompong

Boettcher, Brian R.

Scallen, Terry

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Article abstract of DOI:10.1016/S0960-894X(97)10133-0

The squalene synthase inhibiting properties of farnesyl diphosphate (FPP) mimics, 3 and related analogues, are described. The results indicate that the nonphosphorus-containing N-hydroxyglycine is a novel replacement for the diphosphate group. Further optimization of 3 has led to 12, a new and potent squalene synthase inhibitor.

Full text of DOI:10.1016/S0960-894X(97)10133-0

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