N-Hydroxyglycine derivatives as novel inhibitors of squalene synthase

DOI: 10.1016/S0960-894X(97)10133-0

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 3039 - 3044 (1997)

Update date:2022-08-03

Topics:

Authors:

Wattanasin, Sompong

Boettcher, Brian R.

Scallen, Terry

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(97)10133-0

The squalene synthase inhibiting properties of farnesyl diphosphate (FPP) mimics, 3 and related analogues, are described. The results indicate that the nonphosphorus-containing N-hydroxyglycine is a novel replacement for the diphosphate group. Further optimization of 3 has led to 12, a new and potent squalene synthase inhibitor.

Full text of DOI:10.1016/S0960-894X(97)10133-0

Products guided by the article

Product name:C₂₃H₃₄N₂O₅

Cas No:203120-86-9

R&D Labs maybe for 203120-86-9

Yingkou Sanzheng New Technology Chemical Industry Co., Ltd.

Contact:+86-417-2927806

Address:yingkou
RongCheng K&S Chemical Co.,Ltd

Contact:0631-7336369

Address:rongcheng ,shandong province china
ZHIJIANG ZENVA SINO COMMERCE AND TRADE CO., LTD.

website:http://www.zenvasino.com

Contact:+86-138-72658998

Address:Shibeishan Road,Zhijiang, Hubei, China
Wuhan Hanye Chemical New Material Co.,Ltd

Contact:+86-27-85308141

Address:LiuDian, Panlongcheng Economic Development Zone, HuangPi district, Wuhan, Hubei 430311 P.R.China
Shanghai Rich Chemicals Co., Ltd

website:http://www.richchemical.com

Contact:+86-21-20255798

Address:Pudong Shanghai,China

Relevant to this article

Synthesis of Piperidinone and Azepanone Fused Indoles via a Wagner-Meerwein Type 1,2-Amide Migration of 2-Spiropseudoindoxyls

Doi:10.1055/s-0036-1588138
(2017)
Novel sparteine-mediated enantio-dichotomic formal synthesis of (R)-(-)- and (S)-(+)-curcuphenol

Doi:10.1021/jo001485c
(2001)
The directed lithiation of some 3-acylchromone acetals

Doi:10.1016/S0040-4039(97)10733-X
(1998)
Organic metal-complexes. XXI [1]: Synthesis and structure of 3,5,15,17-tetraoxo-1,7,10,13,19,22-hexaoxacyclotetracosane and 2,12,14,24-tetraoxo-4,7,10,16,19,22-hexaoxa-25-mercurato-bicyclo[11.11.1] pentacosane

Doi:10.1002/prac.19983400207
(1998)
Titanocene(III) chloride mediated radical induced addition-elimination route to the synthesis of racemic and optically active trisubstituted tetrahydrofurans: Formal synthesis of magnofargesin and 7’-epimagnofargesin

Doi:10.1007/s12039-016-1106-0
(2016)
Potent and selective ligands for the dopamine transporter (DAT): Structure-activity relationship studies of novel 4-[2- (diphenylmethoxy)ethyl]-1-(3-phenylpropyl)piperidine analogues

Doi:10.1021/jm970595h
(1998)

Article Doi