Bioorganic and Medicinal Chemistry Letters p. 3039 - 3044 (1997)
Update date:2022-08-03
Topics:
Wattanasin, Sompong
Boettcher, Brian R.
Scallen, Terry
The squalene synthase inhibiting properties of farnesyl diphosphate (FPP) mimics, 3 and related analogues, are described. The results indicate that the nonphosphorus-containing N-hydroxyglycine is a novel replacement for the diphosphate group. Further optimization of 3 has led to 12, a new and potent squalene synthase inhibitor.
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