Bioorganic and Medicinal Chemistry Letters p. 3039 - 3044 (1997)
Update date:2022-08-03
Topics:
Wattanasin, Sompong
Boettcher, Brian R.
Scallen, Terry
The squalene synthase inhibiting properties of farnesyl diphosphate (FPP) mimics, 3 and related analogues, are described. The results indicate that the nonphosphorus-containing N-hydroxyglycine is a novel replacement for the diphosphate group. Further optimization of 3 has led to 12, a new and potent squalene synthase inhibitor.
View MoreTIANJIN ZHONGXIN CHEMTECH CO.,LTD.
Contact:86-022-89880739
Address:10B, Pan China International Center, No. 931 YingKou Road, TangGu, Tianjin, China, 300451
Contact:13120882795；+86-21-34621078;+86-021-31122318
Address:Suite 2,No.2715 Longwu Road
Nanjing Raise Pharmatech Co., Ltd
website:http://www.raisechem.com
Contact:+86-25-58649566
Address:B381,No.606,Ningliu Road,Jiangbei New Area,Nanjing,Jiangsu Province,China
Changzhou Yongfeng Biomedicine Co. Ltd.
website:http://www.yongfengpharm.com
Contact:+86-15006117673
Address:No1,Longxi Road ,Xinbei Zone,Changzhou,JiangsuProvince,PRC
Hangzhou Ocean Chemical Co., Ltd.
website:http://www.hzoceanchem.com
Contact:+86-571-88025872, 28272092, 28272096
Address:Room 623 ,Building No 1 , COFCO Radius Commercial Center Xiwen Road, Xiacheng District, Hangzhou, Zhejiang Province, China
Doi:10.1055/s-0036-1588138
(2017)Doi:10.1021/jo001485c
(2001)Doi:10.1016/S0040-4039(97)10733-X
(1998)Doi:10.1002/prac.19983400207
(1998)Doi:10.1007/s12039-016-1106-0
(2016)Doi:10.1021/jm970595h
(1998)
