Chemical and Pharmaceutical Bulletin p. 1601 - 1604 (1994)
Update date:2022-07-29
Topics:
Yamaguchi
Koga
Kamei
Akima
Kuroki
Hamana
Ohi
Synthesis and pharmacological evaluation of novel 4-[2-(5-ethyl-2-thienyl)]-2-[2-(1-imidazolyl)ethyl]-1(2H)phthalazinone s are described. The phenyl moiety of the phthalazinone skeleton was found to play an important role in both thromboxane A2 synthetase-inhibitory and bronchodilatory activities.
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