Novel antiasthmatic agents with dual activities of thromboxane A2 synthetase inhibition and bronchodilation. III. 4-[2-(5-ethyl-2-thienyl)]-2'-[2-(1-imidazolyl)ethyl]-1(2H)-phthalazino nes

DOI: 10.1248/cpb.42.1601

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1601 - 1604 (1994)

Update date:2022-07-29

Topics:

Authors:

Yamaguchi

Koga Koga

Kamei Kamei

Akima Akima

Kuroki Kuroki

Hamana Hamana

Ohi Ohi

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Article abstract of DOI:10.1248/cpb.42.1601

Synthesis and pharmacological evaluation of novel 4-[2-(5-ethyl-2-thienyl)]-2-[2-(1-imidazolyl)ethyl]-1(2H)phthalazinone s are described. The phenyl moiety of the phthalazinone skeleton was found to play an important role in both thromboxane A₂ synthetase-inhibitory and bronchodilatory activities.

Full text of DOI:10.1248/cpb.42.1601

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