Novel antiasthmatic agents with dual activities of thromboxane A2 synthetase inhibition and bronchodilation. III. 4-[2-(5-ethyl-2-thienyl)]-2'-[2-(1-imidazolyl)ethyl]-1(2H)-phthalazino nes

DOI: 10.1248/cpb.42.1601

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1601 - 1604 (1994)

Update date:2022-07-29

Topics:

Authors:

Yamaguchi

Koga Koga

Kamei Kamei

Akima Akima

Kuroki Kuroki

Hamana Hamana

Ohi Ohi

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1248/cpb.42.1601

Synthesis and pharmacological evaluation of novel 4-[2-(5-ethyl-2-thienyl)]-2-[2-(1-imidazolyl)ethyl]-1(2H)phthalazinone s are described. The phenyl moiety of the phthalazinone skeleton was found to play an important role in both thromboxane A₂ synthetase-inhibitory and bronchodilatory activities.

Full text of DOI:10.1248/cpb.42.1601

NII-Electronic Library Service

Products guided by the article

Product name:2-<2-(5-ethylthenoyl)>-3,4,5,6-tetrahydrobenzoic acid

Cas No:160921-36-8

R&D Labs maybe for 160921-36-8

Nanjing Ruizhi Industry & Technologh Co.，Ltd.

Contact:+86-25-86808110

Address:441-4-A5,NO.12 Longzang Avenue,Yuhuatai District,210039,Nanjing
SINFACHEM LIMITED

Contact:86-25-84683399

Address:605, Phoenix Herui Plaza, No.389, South Taiping Road, Nanjing, China 210002
Qingdao Kylin Trading Co., Ltd.

Contact:0086-532-68979884/58972912/68972263/65/88171519

Address:Room 2308,A building International Trade Center No.230 Changjiang Middle Road of Qingdao Economic Development Zone,Shandong,China.
Changzhou Sunsheng Chem Co., Ltd

Contact:+1-(989)-854-0648

Address:No. 28 Yinshan Rd., Xixiashu Industrial Park
Tianjin Jingye Fine Chemicals Co., Ltd.

Contact:+86-15722078107; +86-22-26911407

Address:Bohua Fine Chemicals Base of Petrochemical Industry Park, Nanhuan Road, Dagang District, Tianjin, 300271, P. R. China

Relevant to this article

Synthesis and properties of hemifluorinated disodium alkanesulfonates

Doi:10.1016/j.jfluchem.2014.04.003
(2014)
Concise synthesis of 1-naphthols under mild conditions through a copper-catalyzed arylation of methyl ketones

Doi:10.1002/adsc.201300728
(2014)
Synthesis of Arylidene-β-lactams via exo-Selective Matsuda-Heck Arylation of Methylene-β-lactams

Doi:10.1021/acs.joc.1c00638
(2021)
N-Trifluoromethylthio-dibenzenesulfonimide: A Shelf-Stable, Broadly Applicable Electrophilic Trifluoromethylthiolating Reagent

Doi:10.1021/acs.joc.6b01178
(2016)
Conventional and microwave assisted synthesis of pyrazolone Mannich bases possessing anti-inflammatory, analgesic, ulcerogenic effect and antimicrobial properties

Doi:10.1016/j.bmcl.2014.04.067
(2014)
ANODIC SYNTHESIS OF BUTENOLIDES FROM β-ETHYLENIC ESTERS DOUBLE CYCLIZATION IN THE PRESENCE OF OLEFINS

Doi:10.1016/S0040-4020(01)86077-4
(1988)

Article Doi