Pyrrolinone-based HIV protease inhibitors. Design, synthesis, and antiviral activity: Evidence for improved transport

DOI: 10.1021/ja00150a011

Source and publish data:

Journal of the American Chemical Society p. 11113 - 11123 (1995)

Update date:2022-07-30

Topics:

Authors:

Smith III, Amos B.

Hirschmann, Ralph

Pasternak, Alexander

Guzman, Mark C.

Yokoyama, Akihisa

Sprengeler, Paul A.

Darke, Paul L.

Emini, Emilio A.

Schleif, William A.

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Article abstract of DOI:10.1021/ja00150a011

Pyrrolinone-based peptidomimetics, the first mimics of β-strands, are potent inhibitors of HIV-1 protease. Importantly, the bis(pyrrolinones) described herein proved to be more active in cellular antiviral assays compared with an analogous peptide-derived

Full text of DOI:10.1021/ja00150a011

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