Enantioselective organocatalytic partial transfer hydrogenation of lactone-fused quinolines

Article abstract of DOI:10.1021/ol5011196

The first enantioselective synthesis of 4-aza-podophyllotoxin derivatives by partial transfer hydrogenation of lactone-fused quinolines was achieved using a chiral Bronsted acid catalyst. This reaction was extended to a large scope of substrates with good yields and enantioselectivities.