Intramolecular Amidoalkylation of Aromatics III. Synthesis of Conformationally Restricted Bridged Peptide Analogues of Phe-Gly

Article abstract of DOI:10.1016/S0040-4020(01)89269-3

Derivatives of the Phe-α-methoxyglycine (4) were prepared and found to undergo stereospecific intramolecular amidoalkylation to give derivatives of 4-amino-2-benzazepin-3-one-1-carboxylic acid 5 (ABZC).The cyclic compounds 5a-g are conformationally restri