Metalation of diazines. XI. Directed ortho-lithiation of fluoropyrimidines and application to synthesis of an azacarboline

DOI: 10.1002/jhet.5570310602

Source and publish data:

Journal of Heterocyclic Chemistry p. 1311 - 1315 (1994)

Update date:2022-08-04

Topics:

Authors:

Ple Ple

Turck Turck

Heynderickx

Queguiner

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1002/jhet.5570310602

For the first time fluoropyrimidines were successfully lithiated. The resulting lithio derivatives were reacted with various electrophiles for the synthesis of new pyrimidines. The synthesis of an azacarboline derivative is reported.

Full text of DOI:10.1002/jhet.5570310602

Products guided by the article

Product name:5-Pyrimidinemethanol,2,4-difluoro-alpha-methyl-(9CI)

Cas No:161123-97-3

R&D Labs maybe for 161123-97-3

ZhangJiaGang YaRui Chemical Co.,Ltd.

Contact:0512-58360968

Address:China JiangSu Province Zhang Jia Gang City YangShe Oriental Plaza Building 10 B307
Chengdu Green technology Co.,Ltd.

Contact:86-28-82608355

Address:C9 ,Economic Headquarters, Economic Development Zone, Chengdu.
Jiangsu Institute of Ecomones Co., Ltd

website:http://www.jsmone.com

Contact:+86-519-82821700

Address:95 Huanyuan N. Road, Jintan, Jiangsu, China
xujianqiang

Contact:86-21-57725962

Address:shanghai
Shangyu Sanhechemicals Co.,LTD.

Contact:86-0571-56696839

Address:Num.2952,Nanhuan Road,Binjiang District,Hangzhou,China

Relevant to this article

Electroactive polymers containing pendant harmane, phenoxazine or carbazole rings as host materials for OLEDs

Doi:10.1016/j.dyepig.2014.04.034
(2014)
Enantioselective nucleophile-catalyzed synthesis of tertiary alkyl fluorides via the α-Fluorination of ketenes: Synthetic and mechanistic studies

Doi:10.1021/ja5044209
(2014)
Cyclopent-4-ene-1,3-diones: A new class of herbicides acting as potent photosynthesis inhibitors

Doi:10.1021/jf5014605
(2014)
Rhodium-catalyzed transfer hydrogenation with aminophosphines and analysis of electrical characteristics of rhodium(I) complex/n-Si heterojunctions

Doi:10.1002/aoc.3140
(2014)
Direct synthesis of α-ketothioamides from aryl methyl ketones and amines via I₂-promoted sp³ C-H functionalization

Doi:10.1016/j.tet.2014.05.045
(2014)
Clathrochelates meet phosphorus: Thiophosphorylation of Fe(ii) dichloroclathrochelate precursor, synthesis of N,S-donor macrobicyclic ligands and their Pd(ii) complexes as potent catalysts of Suzuki cross-coupling reaction

Doi:10.1039/c3dt53590h
(2014)

Article Doi