Metalation of diazines. XI. Directed ortho-lithiation of fluoropyrimidines and application to synthesis of an azacarboline

Article abstract of DOI:10.1002/jhet.5570310602

For the first time fluoropyrimidines were successfully lithiated. The resulting lithio derivatives were reacted with various electrophiles for the synthesis of new pyrimidines. The synthesis of an azacarboline derivative is reported.