Synthesis of P1 Aspartate-Based Peptide Acyloxymethyl and Fluoromethyl Ketones as Inhibitors of Interleukin-1β-Converting Enzyme

DOI: 10.1016/0040-4039(94)88361-0

Source and publish data:

Tetrahedron Letters p. 9693 - 9696 (1994)

Update date:2022-08-03

Topics: Synthesis Inhibitors Fluoromethyl Ketones Interleukin-1β-converting enzyme

Authors:

Revesz, Laszlo

Briswalter, Chantal

Heng, Richard

Leutwiler, Albert

Mueller, Rudolf

Wuethrich, Hans-Juerg

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Article abstract of DOI:10.1016/0040-4039(94)88361-0

Improved procedures have been developed for the synthesis of P1 aspartate-based 2,6-dichlorobenzoyloxymethyl ketone 1 and fluoromethyl ketone 2, the prodrugs of two potent ICE-inhibitors. 1 was prepared from (R)-trans-4,5-O-isopropylidene-4,5-dihydroxy-2-

Full text of DOI:10.1016/0040-4039(94)88361-0

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