Synthesis p. 1294 - 1300 (1994)
Update date:2022-08-03
Topics:
Pommier
Pons
A key step in a short asymmetric synthesis of the potent pancreatic lipase inhibitor (-)-tetrahydrolipstatin (2) is a Lewis acid-catalysed [2 + 2] cycloaddition of n-hexyl(trimethylsilyl)ketene (5) to (R)-3-(tertbutyldimethylsilyloxy)tetradecanal (4a).
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Doi:10.1016/j.bmc.2014.05.001
(2014)Doi:10.1039/c5ra12856k
(2015)Doi:10.1039/c4ob00123k
(2014)Doi:10.1016/j.ejmech.2014.05.076
(2014)Doi:10.1002/anie.201807749
(2018)Doi:10.1039/c4dt01236d
(2014)
