An asymmetric synthesis of (-)-tetrahydrolipstatin

DOI: 10.1055/s-1994-25684

Source and publish data:

Synthesis p. 1294 - 1300 (1994)

Update date:2022-08-03

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Authors:

Pommier Pommier

Pons Pons

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Article abstract of DOI:10.1055/s-1994-25684

A key step in a short asymmetric synthesis of the potent pancreatic lipase inhibitor (-)-tetrahydrolipstatin (2) is a Lewis acid-catalysed [2 + 2] cycloaddition of n-hexyl(trimethylsilyl)ketene (5) to (R)-3-(tertbutyldimethylsilyloxy)tetradecanal (4a).

Full text of DOI:10.1055/s-1994-25684

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