Synthesis of a 4'-selenated 2-deoxyadenosine derivative: A novel precursor suitable for the preparation of modified oligonucleotides

Article abstract of DOI:10.1055/s-1994-25686

Swern oxidation, subsequent selenation and reduction gave the selenated deoxyadenosine derivatives 4a and 4b. Isomer 4b was converted into the phosphoramidite 7, a building block for modified oligonucleotides 8.