Synthesis of a 4'-selenated 2-deoxyadenosine derivative: A novel precursor suitable for the preparation of modified oligonucleotides

DOI: 10.1055/s-1994-25686

Source and publish data:

Synthesis p. 1310 - 1312 (1994)

Update date:2022-08-04

Topics: Synthesis Precursor Derivative Oligonucleotides Modified oligonucleotides

Authors:

Giese Giese

Erdmann Erdmann

Schafer Schafer

Schwitter

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Article abstract of DOI:10.1055/s-1994-25686

Swern oxidation, subsequent selenation and reduction gave the selenated deoxyadenosine derivatives 4a and 4b. Isomer 4b was converted into the phosphoramidite 7, a building block for modified oligonucleotides 8.

Full text of DOI:10.1055/s-1994-25686

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