A Novel Synthetic Route to Enantiomers of ε-Hydroxynorleucine and ε-Chloronorleucine from L- and D,L-Lysine

Article abstract of DOI:10.1016/0040-4039(94)02278-J

Thermal rearrangement of (S)- or (R)-hexahydro-1-nitroso-3-phthalimido-2H-azepin-2-one to te corresponding lactone followed by nucleophilic ring opening of the latter gives ε-chloro- or ε-hydroxynorleucine.