Synthesis of the first penicillin derivatives with medium-sized lactam ring and of related thiazolidines

Article abstract of DOI:10.1002/ardp.19953280302

The novel concept of penicillin derivatives 4 with a medium-sized instead of a β-lactam ring is presented. Two synthetic paths were invented, resulting in the evaluation of the synthetic potential in the succinic, glutaric, and adipic acid series: A numbe