Synthesis of 2,4-diaza-4-deoxypodophyllotoxin, a new analogue of podophyllotoxin possessing antitumour activity

DOI: 10.1039/c39950000049

Source and publish data:

Journal of the Chemical Society. Chemical communications p. 49 - 50 (1995)

Update date:2022-08-03

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Authors:

Hitotsuyanagi

Naka Naka

Yamagami

Fujii Fujii

Tahara Tahara

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Article abstract of DOI:10.1039/c39950000049

2,4-Diaza-4-deoxypodophyllotoxin 4 and its cis analogue 14 are synthesised stereoselectively from 3,4-methylenedioxyaniline 5, and show significant activity against vincristine-resistant P-388 leukaemia in vivo.

Full text of DOI:10.1039/c39950000049

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