Erratum: Amides are excellent mimics of phosphate internucleoside linkages and are well tolerated in short interfering RNAs (Nucleic Acids Research (2014) 42:10 (6542-6551) DOI:10.1093/nar/gku235)

Full text of DOI:10.1093/nar/gku669

10870 Nucleic Acids Research, 2014, Vol. 42, No. 16
doi: 10.1093/nar/gku669
Erratum
Amides are excellent mimics of phosphate internucleoside linkages and are well tolerated in short interfering RNAs
Daniel Mutisya, Chelliah Selvam, Benjamin D. Lunstad, Pradeep S. Pallan, Amanda Haas, Devin Leake, Martin Egli, and
Eriks Rozners
Nucl. Acids Res. (2014) 42 (10): 6542-6551. doi: 10.1093/nar/gku235.
First published online: May 9, 2014. Corrected after print: June 2, 2014.
Due to an error in production, in the original version of this Article published on May 9, 2014, an oversized version of
Figure 9 was inserted instead of Scheme 1. Scheme 1 was missing. These errors have now been corrected in the new online
version of the Article and Scheme 1 is included below. The Publisher wishes to apologise to the Authors for this error.
Scheme 1. Synthesis of dimeric r(UAM1U) and r(UAM1A) phosphoramidites.a
aSteps: (a) TFA, THF, H2O 0 ◦C, 4 h, 92%; (b) p-methoxytrityl chloride, pyridine, 0 ◦C to rt, 14 h, 85%; (c) OsO4, 4-methylmorpholine N-oxide, dioxane, rt,
10 h, then NaIO4 in water, rt, 12 h, 95%; (d) NaClO4, NaH2PO4, 2-methylbut-2-ene, t-BuOH, THF water, rt, 1 h, 82%; (e) DIEA, Bu2SnCl2, dichloroethane,
rt, 1 h, then add TOM-Cl, 80 ◦C, 45 min, 39%; (f) H2S, pyridine, water, rt, 14 h 93%; (g) HBTU, HOBt, DIEA, CH2Cl2, rt, 12 h, 95% 11a, 86% 11b; (h)
DIEA, ClP(OCH2CH2CN)N(iPr)2, CH2Cl2, rt, 7 h, 71% 11a, 60% 11b.
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