Stereoselective 'ene' reaction of allylsilanes with amino aldehydes. An application to the synthesis of potential HIV-1 protease inhibitors

Article abstract of DOI:10.1021/jo00093a006

2-Substituted 3-(trimethylsilyl)-1-propenes react with N-Doc-α-amino aldehydes in the presence of BF₃·OEt₂ to give homoallylic alcohols, potential intermediates for the synthesis of hydroxyethylene peptide isosteres. The reaction giv