Stereoselective 'ene' reaction of allylsilanes with amino aldehydes. An application to the synthesis of potential HIV-1 protease inhibitors

DOI: 10.1021/jo00093a006

Source and publish data:

Journal of Organic Chemistry p. 3762 - 3768 (1994)

Update date:2022-07-30

Topics:

Authors:

D'Aniello

Mann Mann

Mattii Mattii

Taddei Taddei

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jo00093a006

2-Substituted 3-(trimethylsilyl)-1-propenes react with N-Doc-α-amino aldehydes in the presence of BF₃·OEt₂ to give homoallylic alcohols, potential intermediates for the synthesis of hydroxyethylene peptide isosteres. The reaction giv

Full text of DOI:10.1021/jo00093a006

Products guided by the article

Product name:(4S,5S)-5-((tert-Butoxycarbonyl)amino)-1-chloro-6-phenyl-2-((trimethylsilyl)methyl)-1-hexen-4-ol

Cas No:161758-23-2

R&D Labs maybe for 161758-23-2

Kaymossy BioChem Tech Co., Ltd

website:http://www.kaimosi.com

Contact:0571-87191913/0571-87199097

Address:Room 215, Building 3rd, No.288 Ningxia Road, Qingdao city, China
Xi'an Costrong Pharmaceutical Co., Ltd.

Contact:029- 68576496

Address:Room 2004,Shuibao Building,No.190,South Erhuan Rd, Yanta District,Xi'an,Shaan Xi,China
Lanzhou SchiffChem Co.,Ltd

Contact:86-931-8272767

Address:Room 602, No.461, Nanchang Road, Chengguan District, Lanzhou City, China PRC
Hangzhou utanpharma Co., Ltd

Contact:86-571-87758773

Address:Room604 ,6F, Block A1-3 Xixi Plaza,No. 588 Wenyi West RD, Hangzhou,310012, China
NANCHANG QINZHI SCI&TEC.CO.,LTD(expird)

Contact:+86-13687004106

Address:Hero South Road,Hero Zone,Nanchang,Jiangxi,China

Relevant to this article

Palladium catalysed queuing processes. Part 1: Termolecular cyclization-anion capture employing carbon monoxide as a relay switch and hydride, organotin(IV) or boron reagents

Doi:10.1016/S0040-4020(00)01103-0
(2001)
Comparison of backbone modification in protein β-sheets by α→γ residue replacement and α-residue methylation

Doi:10.1039/c4ob00886c
(2014)
Amine-selective bioconjugation using arene diazonium salts

Doi:10.1021/ol5016509
(2014)
1-<1-<4-<(N-Acetyl-4-piperidinyl)oxy>-2-methoxybenzoyl>piperidin-4-yl>-4H-3,1-benzoxazin-2(1H)-one (L-371,257): A New, Orally Bioavailable, Non-Peptide Oxytocin Antagonist

Doi:10.1021/jm00023a002
(1995)
Direct access to 4,8-functionalized benzo[1,2-b:4,5-b′]dithiophenes with deep low-lying HOMO levels and high mobilities

Doi:10.1039/c4ta01226g
(2014)
A direct synthesis of selenophenes by Cu-catalyzed one-pot addition of a selenium moiety to (E,E)-1,3-dienyl bromides and subsequent nucleophilic cyclization

Doi:10.1021/ol501820e
(2014)

Article Doi