Synthesis of N-substituted 7β-diprenorphine derivatives

Article abstract of DOI:10.1080/00397919508013419

The separation of thevinone (2a) and β-thevinone (2b), as well as that of dihydrothevinone (3a) and β-dihydrothevinone (3b) was accomplished. By the application of various procedures numerous new N-substituted Diprenorphine analogues (8a-f) with 7R absolute configuration were synthesized. Detailed pharmacological investigation of the prepared compounds may contribute to a better understanding of the structure-activity relationship of morphine alkaloids.

Full text of DOI:10.1080/00397919508013419

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Synthetic Communications: An
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Synthesis of N-Substituted 7β-
Diprenorphine Derivatives
János Marton a , Szilárd Miklòs a , Sàndor Hosztafi a
& Sándor Makleit b
a Alkaloida Chemical Company Ltd. , H-4440,
Tiszavasvári, Hungary
b Department of Organic Chemistry , L. Kossuth
University , P. O. Box 20., H-4010, Debrecen,
Hungary
Published online: 23 Sep 2006.
To cite this article: János Marton , Szilárd Miklòs , Sàndor Hosztafi & Sándor
Makleit (1995) Synthesis of N-Substituted 7β-Diprenorphine Derivatives, Synthetic
Communications: An International Journal for Rapid Communication of Synthetic
Organic Chemistry, 25:6, 829-848, DOI: 10.1080/00397919508013419
To link to this article: http://dx.doi.org/10.1080/00397919508013419
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