Communication
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Scheme 4 CuH and Stryker’s reagent-catalyzed 3-phosphorylation.
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Scheme 5 The proposed mechanism for CuCl-catalyzed cross-coupling
by hydrogen (H2) removal.
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LnCuH (1D) is produced and reacts with diphenylphosphine oxide
in order to form intermediate LnCuP(O)Ph2 1A again by releasing
monomolecular hydrogen and HCl into the catalytic cycle.
In summary, we have developed a highly efficient protocol
for the preparation of various 3-phosphoindoles via a copper-
catalyzed cross-coupling reaction by hydrogen (H2) removal. We
expect that this simple and atom-economical template can be
structurally modified and applied to the construction of other
C–X (X = C, N) bonds.
´
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´
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We are grateful for the NSFC (No. 21272100) and Program
for New Century Excellent Talents in University (NCET-11-0215
and lzujbky-2013-k07) financial support.
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