Structure-based design of β1i or β5i specific inhibitors of human immunoproteasomes

Article abstract of DOI:10.1021/jm500716s

Mammalian genomes encode seven catalytic proteasome subunits, namely, β1c, β2c, β5c (assembled into constitutive 20S proteasome core particles), β1i, β2i, β5i (incorporated into immunoproteasomes), and the thymoproteasome-specific subunit β5t. Extensive r