European Journal of Medicinal Chemistry p. 687 - 697 (2014)
Update date:2022-08-04
Topics: Synthesis Column chromatography NMR spectroscopy Heterocyclic compounds Apoptosis Mass spectrometry (MS) IC50 Cytotoxic activity Aryl group Mechanism of Action Docking Studies Cell Lines Flow Cytometry Imidazo[2,1-b][1,3,4]thiadiazole MTT assay
Kumar, Sujeet
Hegde, Mahesh
Gopalakrishnan, Vidya
Renuka, Vinaya Kumar
Ramareddy, Sureshbabu A.
De Clercq, Erik
Schols, Dominique
Gudibabande Narasimhamurthy, Anil Kumar
Raghavan, Sathees C.
Karki, Subhas S.
The cytotoxic activity of a new series of 2-(4′-chlorobenzyl)-5,6- disubstituted imidazo[2,1-b][1,3,4]thiadiazoles against different human and murine cancer cell lines is reported. Among the tested compounds, two derivatives namely 2-(4-chlorobenzyl)-6-(2
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Doi:10.1002/adsc.201400223
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