Advanced Synthesis and Catalysis p. 4714 - 4719 (2021)
Update date:2022-09-26
Topics:
He, Jiayin
Huang, An
Ling, Fei
Wang, Shiliang
Wang, Yifan
Wang, Ze
Zhao, Xianghua
Zhong, Weihui
An iridium/f-diaphos catalytic system for the enantioselective hydrogenation of α-substituted β-ketoesters via dynamic kinetic resolution is reported. The desired anti β’-hydroxy-β-amino esters were obtained in moderate to good yields (60–95%) with 72–99% ees and 91:9 to 99:1 drs. This protocol tolerates various functional groups and could be easily conducted on gram scale with lower catalyst loading (TON up to 9100). (Figure presented.).
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