A simple method of preparation of 7-alkyl-7-azabicyclo[2.2.1] heptanes

Article abstract of DOI:10.1016/0040-4039(95)00051-D

Action of triphenylphosphine - carbon tetrachloride on the trans-4-alkylaminocyclohexanols leads to 7-alkyl-7-azabicyclo[2.2.1]heptanes in the good yields. The starting aminoalcohols are easily available from the monoethylene ketal of 1,4-cyclohexanedione and primary amines in a four step process without isolation of intermediates.