Synthesis and biological activity of thiazolylindolequinones, analogues of the natural product BE 10988

DOI: 10.1021/jm00006a024

Source and publish data:

Journal of Medicinal Chemistry p. 1039 - 1043 (1995)

Update date:2022-08-03

Topics:

Authors:

Moody Moody

Swann Swann

Houlbrook

Stephens

Stratford

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Article abstract of DOI:10.1021/jm00006a024

A number of analogues of the naturally occurring thiazolylindolequinone BE 10988, a reported potent inhibitor of topoisomerase II, have been prepared and evaluated. The compounds were synthesized from 4-(benzyloxy)-5-methoxy- l-methylindole by appropriate

Full text of DOI:10.1021/jm00006a024

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Product name:4-(benzyloxy)-3-(chloroacetyl)-5-methoxy-1-methylindole

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