Bioorganic and Medicinal Chemistry Letters p. 2551 - 2556 (1997)
Update date:2022-08-05
Topics:
Connolly, Peter J.
Wetter, Steven K.
Beers, Kimberly N.
Hamel, Stephanie C.
Haynes-Johnson, Donna
Kiddoe, Margaret
Kraft, Pat
Lai, Muh Tsann
Campen, Carolyn
Palmer, Stephen
Phillips, Audrey
Research directed toward the discovery of non-steroidal ligands for steroid receptors led to the preparation of a series of substituted 1-phenyl-7-benzyltetrahydroindazole-3-carboxaldehydes. Appropriately substituted 3-formyl analogs (4) were found to bind with high affinity to progesterone receptors and showed agonist activity in human T47D cells but were inactive in several in vivo models for progestational activity.
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