Structure-Activity Relationships of 9-Alkyladenine and Ribose-Modified Adenosine Derivatives at Rat A3 Adenosine Receptors

DOI: 10.1021/jm00010a017

Source and publish data:

Journal of Medicinal Chemistry p. 1720 - 1735 (1995)

Update date:2022-08-05

Topics: Structure-activity relationships Chemical Synthesis High-Throughput Screening Structure-activity relationship study Radioligand Binding Assay

Authors:

Jacobson, Kenneth A.

Siddiqi, Suhaib M.

Olah, Mark E.

Ji, Xiao-duo

Melman, Neli

et al. et al.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00010a017

9-Alkyladenine derivatives and ribose-modified N⁶-benzyladenosine derivatives were synthesized in an effort to identify selective ligands for the rat A₃ adenosine receptor and leads for the development of antagonists.The derivatives

Full text of DOI:10.1021/jm00010a017

Products guided by the article

Product name:Acetic acid (2R,3R,4R)-4-acetoxy-2-[2-chloro-6-(3-iodo-benzylamino)-purin-9-yl]-tetrahydro-furan-3-yl ester

Cas No:163042-93-1

R&D Labs maybe for 163042-93-1

Tianjin Crest Pharmaceutical R&D Co., Ltd. （Tianjin Yao Technology Development Co., Ltd.）(expird)

Contact:+86-22-66211386

Address:Building B5-405, No, 80 4th Avenue, TEDA, Tianjin, China P.R. 300457
Xinchang Yueding Chemical Co., Ltd.

Contact:86-571-56926323

Address:NO.90 BEIMENCHENGWAI CHENGGUAN TOWN XINCHANG
Wansheng

Contact:86-21-31200601

Address:Room1618,FangzhengDaSha,No.1122 Xinjinqiao Road,Pudong New District,Shanghai ,China
Zhejiang Sanmei Chemical Industry Co., Ltd

Contact:86-579-87633213

Address:Huchu Industrial Zone, Qingnian Rd., Wuyi County, Zhejiang Prov., China.
Wuhan Kemi-Works Chemical Co., Ltd

website:http://www.kemiworks.com

Contact:86-27-85736489

Address:Rm. 1503, No. 164, Jianghan North Rd., Wuhan, 430022 China

Relevant to this article

Improved conditions for the proline-catalyzed aldol reaction of acetone with aliphatic aldehydes

Doi:10.1055/s-0033-1340919
(2014)
Rutenium(II)-Catalyzed Reaction of 1,4-Epiperoxides

Doi:10.1021/ja00371a041
(1982)
Photocatalytic decarboxylative [2 + 2 + m] cyclization of 1,7-enynes mediated by tricyclohexylphosphine and potassium iodide

Doi:10.1021/acs.orglett.0c03182
(2020)
Functionalized o-bis(chloromethyl)pyridines as precursors for pyridine o-quinodimethane analogues and their [4 + 2] cycloadducts

Doi:10.1016/0040-4039(95)00169-D
(1995)
Lipophilic antifolates as agents against opportunistic infections. 1. Agents superior to trimetrexate and piritrexim against Toxoplasma gondii and Pneumocystis carinii in in vitro evaluations

Doi:10.1021/jm950760y
(1996)
Synthesis and characterization of [PPh₄][M(diod)₂], M = Ni, Pd, Cu or Au; crystal structure of [PPh₄][Cu(diod)₂]

Doi:10.1016/S0277-5387(96)00381-6
(1997)

Article Doi