Ni-catalyzed nucleophilic conjugate additions of Grignard and organozincate reagents to substituted 4-vinylpyridines. General synthesis of phosphodiesterase IV inhibitors

DOI: 10.1016/S0040-4020(97)10217-4

Source and publish data:

Tetrahedron p. 1185 - 1195 (1998)

Update date:2022-08-05

Topics:

Authors:

Houpis, Ioannis N.

Lee, Jaemoon

Dorziotis, Ilias

Molina, Audrey

Reamer, Bob

Volante Volante

Reider, Paul J.

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Article abstract of DOI:10.1016/S0040-4020(97)10217-4

Alkyl, aryl, and vinyl Grignard reagents were added to olefin II under Ni(acac)₂ or Cl₂Ni(PPh₃)₂ catalysis to give products with the general formula I in 74-95% yield. Organozincates gave similar results with Ni(acac)₂ as the catalyst.

Full text of DOI:10.1016/S0040-4020(97)10217-4

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Product name:Pyridine,4-[(2S)-2-[3-(cyclopentyloxy)-4-methoxyphenyl]-2-phenylethyl]-

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