Ni-catalyzed nucleophilic conjugate additions of Grignard and organozincate reagents to substituted 4-vinylpyridines. General synthesis of phosphodiesterase IV inhibitors

DOI: 10.1016/S0040-4020(97)10217-4

Source and publish data:

Tetrahedron p. 1185 - 1195 (1998)

Update date:2022-08-05

Topics:

Authors:

Houpis, Ioannis N.

Lee, Jaemoon

Dorziotis, Ilias

Molina, Audrey

Reamer, Bob

Volante Volante

Reider, Paul J.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4020(97)10217-4

Alkyl, aryl, and vinyl Grignard reagents were added to olefin II under Ni(acac)₂ or Cl₂Ni(PPh₃)₂ catalysis to give products with the general formula I in 74-95% yield. Organozincates gave similar results with Ni(acac)₂ as the catalyst.

Full text of DOI:10.1016/S0040-4020(97)10217-4

Products guided by the article

Product name:Pyridine,4-[(2S)-2-[3-(cyclopentyloxy)-4-methoxyphenyl]-2-phenylethyl]-

Cas No:162542-91-8

R&D Labs maybe for 162542-91-8

Jiaozuo Zhongwei Special Products Pharmaceutical Co.,Ltd.

website:http://www.zw-pvp.com

Contact:15302105619

Address:Jiaozuo,Henan,China (Mainland)
ShenZhen InnoSyn Biotech Co.,Ltd

website:http://www.innosyns.com

Contact:+86-755-28351685

Address:Floor 5 & 6, Building A1, HAIKEXING Strategic Innovative Industrial Park, 16 BaoShan Road, PingShan District
HEBEI BRANT PHARMACEUTICAL

Contact:+86-0311-84455288-844

Address:Mayu Industrial Park, Jinzhou, Hebei, China.
EnBridge PharmTech Co., Ltd.

website:http://www.enbridgepharm.com

Contact:+86-510-83591909

Address:Huishan Zone, Wuxi City, Jiangsu Province, P.R.China
Suzhou Ryan Pharmachem Technology Co.,Ltd

Contact:+86-0512-68780025

Address:B-301,No.2 Taishan Road,Suzhou New District,Jiangsu,P.R. China

Relevant to this article

Synthesis, biological evaluation and molecular modeling study of pyrazole derivatives as selective COX-2 inhibitors and anti-inflammatory agents

Doi:10.1016/j.bioorg.2014.05.004
(2014)
Studies on [PtCl₂]- or [AuCl]-catalyzed cyclization of 1-(indol-2-yl)-2,3-allenols: The effects of water/steric hindrance and 1,2-migration selectivity

Doi:10.1002/chem.201402423
(2014)
Fe-Catalyzed Selective Cyclopropanation of Enynes under Photochemical or Thermal Conditions

Doi:10.1021/acs.orglett.9b04521
(2020)
Preparation of alkyl-substituted indoles in the benzene portion. Part 13. Enantiospecific synthesis of mitosene analogues related to FR 900482 and FR 66979

Doi:10.1248/cpb.43.37
(1995)
A New Synthesis of the Naturally Occurring Free Radical Scavenger Carazostatin

Doi:10.1246/cl.1995.289
(1995)
Facile Synthesis of Protected C-terminal Peptide Segments by Fmoc/Bu^t Solid-phase Procedures on N-Fmoc-9-amino-xanthen-3-yloxymethyl Polystyrene Resin

Doi:10.1039/c39950000589
(1995)

Article Doi