Ni-catalyzed nucleophilic conjugate additions of Grignard and organozincate reagents to substituted 4-vinylpyridines. General synthesis of phosphodiesterase IV inhibitors

DOI: 10.1016/S0040-4020(97)10217-4

Source and publish data:

Tetrahedron p. 1185 - 1195 (1998)

Update date:2022-08-05

Topics:

Authors:

Houpis, Ioannis N.

Lee, Jaemoon

Dorziotis, Ilias

Molina, Audrey

Reamer, Bob

Volante Volante

Reider, Paul J.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4020(97)10217-4

Alkyl, aryl, and vinyl Grignard reagents were added to olefin II under Ni(acac)₂ or Cl₂Ni(PPh₃)₂ catalysis to give products with the general formula I in 74-95% yield. Organozincates gave similar results with Ni(acac)₂ as the catalyst.

Full text of DOI:10.1016/S0040-4020(97)10217-4

Products guided by the article

Product name:Pyridine,4-[(2S)-2-[3-(cyclopentyloxy)-4-methoxyphenyl]-2-phenylethyl]-

Cas No:162542-91-8

R&D Labs maybe for 162542-91-8

GN chemicals co.,ltd

Contact:86 311 85902108 / 85902109

Address:room 1001-1005 ,huanghe Road ,shijiazhuang ,China
Beijing Stable Chemcial Co.ltd

Contact:86-10-63785052

Address:A1301 Technological Edifice. No.4 FuFeng Road,FengTai District, Beijing. China
Jiangsu Cale New Material Co.ltd

Contact:+86-515-88334667/88203550

Address:Zhongshan 3rd Road, Coastal Chemical Industry Park, Yancheng, Jiangsu, China
Shandong Xingshun New Material Co., Ltd.

website:http://www.sd-xingshun.com

Contact:+86-519-86461196

Address:Middle of Luhua East Road, Dingtao District
AUSHUN PHARMACEUTICAL TECHNOLOGY CO,.LTD

Contact:+86-25-86883560 15951806178

Address:14 Dayingbi, Zhujiang Rd. East, Nanjing, Jiangsu, China.

Relevant to this article

Synthesis, biological evaluation and molecular modeling study of pyrazole derivatives as selective COX-2 inhibitors and anti-inflammatory agents

Doi:10.1016/j.bioorg.2014.05.004
(2014)
Studies on [PtCl₂]- or [AuCl]-catalyzed cyclization of 1-(indol-2-yl)-2,3-allenols: The effects of water/steric hindrance and 1,2-migration selectivity

Doi:10.1002/chem.201402423
(2014)
Fe-Catalyzed Selective Cyclopropanation of Enynes under Photochemical or Thermal Conditions

Doi:10.1021/acs.orglett.9b04521
(2020)
Preparation of alkyl-substituted indoles in the benzene portion. Part 13. Enantiospecific synthesis of mitosene analogues related to FR 900482 and FR 66979

Doi:10.1248/cpb.43.37
(1995)
A New Synthesis of the Naturally Occurring Free Radical Scavenger Carazostatin

Doi:10.1246/cl.1995.289
(1995)
Facile Synthesis of Protected C-terminal Peptide Segments by Fmoc/Bu^t Solid-phase Procedures on N-Fmoc-9-amino-xanthen-3-yloxymethyl Polystyrene Resin

Doi:10.1039/c39950000589
(1995)

Article Doi