Resolution of Racemic Carboxylic and Sulfonic Acids via D-Xylose Derived New Cyclic Carbamate Reagents (Oxazolidin-2-ones)

Article abstract of DOI:10.1016/0957-4166(94)00347-E

Two new chiral oxazolidin-2-ones have been easily prepared from D-xylose and studied as chiral derivatizing agents (CDA's) for the resolution of racemic carboxylic and sulfonic acids.The resultant diastereomers are readily separated by chromatographic methods and easily hydrolyzed to isolate the resolved materials in high optical purities and to return the CDA's for reuse.