Tetrahedron Letters p. 5661 - 5665 (1999)
Update date:2022-08-05
Topics:
Eckert, Jeffrey
Chan, Tze-Ming
Osterman, Rebecca M.
Lambert, Joseph B.
Gala, Dinesh
A mechanistic study of the simple sequential N-arylation of piperazine suggests that in an electron-withdrawing group (EWG) containing N-arylated piperazines, hydrogen bonding of the secondary amine hydrogen is important for its non-metal catalyzed conversion to N,N'-diaryl piperazines. A combination of synthetic experiments, molecular modeling, and NMR studies were carried out to test this hypothesis.
View MoreShanghai Korey Pharm Co.,Ltd.(expird)
Contact:021-61840961 021-61840962
Address:No.157,Zhuguang Rd, Qingpu, Shanghai, China
ZHANGJIAGANG FREE TRADE ZONE YONG HAN INTERNATIONAL TRADING CO., LTD(expird)
Contact:86 512 57910558
Address:qianjin M road
Melone Pharmaceutical Co., ltd
Contact:+86-411 82593920, 82593631
Address:No 232, JInma Roda, Development Zone, Dalian, China
ShangHai Ruiyi Medical Technology Co.,Ltd.
Contact:+86-21-54718086
Address:No951 Jianchuan RD，Minhang District
Zhenjiang Haitong Chemical Industry Co., Ltd.
Contact:+86 (511) 8448-0369
Address:Baoyan Town, Dantu District, Zhenjiang City, Jiangsu, China
Doi:10.1002/ejoc.201402460
(2014)Doi:10.1007/s11164-015-2112-4
(2016)Doi:10.1021/ja502824c
(2014)Doi:10.1002/pola.27223
(2014)Doi:10.1039/c4ra02174f
(2014)Doi:10.1016/0022-328X(94)05104-J
(1995)
