Synthesis of 1,3-dihydro-3,3-dimethyl-2H-indol-2-one derivatives as possible nonsteroidal cardiotonics

DOI: 10.1002/jhet.5570320101

Source and publish data:

Journal of Heterocyclic Chemistry p. 1 - 11 (1995)

Update date:2022-08-04

Topics:

Authors:

Lee Lee

Huang Huang

Lin Lin

Shih Shih

Lee Lee

Lin Lin

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Article abstract of DOI:10.1002/jhet.5570320101

New substituted 1,3-dihydro-3,3-dimethyl-2H-indol-2-one derivatives 19-29 and 34-43 were synthesized and examined for their inotropic activity in isolated dog ventricular tissues. Among them, compound 26 (2-(2,3-dimethoxybenzylamino)-N-(3,3,7-trimethyl-2-oxo-2,3-dihydro-1H-i ndol-5-yl)acetamide) showed very potent activity.

Full text of DOI:10.1002/jhet.5570320101

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