Synthesis of pyrimidine 2'3'-dideoxy-2-thionucleosides

Article abstract of DOI:10.1080/15257779508014664

2'-Deoxyuridine 8a and thymidine 8b were converted in eight steps and in satisfactory overall yields into 2',3'-dideoxy-2-thiouridine (ddTU) 6a and 3'-deoxy-2-thiothymidine (ddTT) 6b, respectively. A three-step procedure is described for the conversion of ddTU 6a and ddTT 6b into the corresponding 2',3'-dideoxycytidine derivatives (ddTC 7a and ddMTC 7b, respectively) in good overall yield.

Full text of DOI:10.1080/15257779508014664

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Nucleosides and Nucleotides
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Synthesis of Pyrimidine 2′,3′-
Dideoxy-2-Thionucleosides
Bhalchandra V. Joshi a , Colin B. Reese a & Chamakura V. N. S.
Varaprasad a
a Department of Chemistry , King's College London , Strand,
London, WC2R 2LS, UK
Published online: 24 Sep 2006.
To cite this article: Bhalchandra V. Joshi , Colin B. Reese & Chamakura V. N. S. Varaprasad (1995)
Synthesis of Pyrimidine 2′,3′-Dideoxy-2-Thionucleosides, Nucleosides and Nucleotides, 14:1-2,
209-218, DOI: 10.1080/15257779508014664
To link to this article: http://dx.doi.org/10.1080/15257779508014664
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