Tetrahedron Letters p. 1401 - 1404 (1995)
Update date:2022-07-30
Topics:
Lainton, Julia A. H.
Huffman, John W.
Martin, Billy R.
Compton, David R.
The design and synthesis of a series of 1-alkyl-3-(1-naphthoyl)pyrroles is described. Molecular modeling studies were employed to aid in the design of these compounds. During the course of the synthesis the Friedel-Crafts reactions of N-aryl sulfonyl pyrroles were reinvestigated. The title compounds (4) were subjected to pharmacological evaluation and the data obtained have enabled these pyrroles to be classified as cannabinoids.
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Doi:10.1126/science.1254976
(2014)Doi:10.1002/aoc.5449
(2020)Doi:10.1016/0008-6215(67)85013-4
(1967)Doi:10.1002/cjoc.201400223
(2014)Doi:10.1021/jo00103a057
(1994)Doi:10.1021/ja00122a001
(1995)
