Regioselectivity and stereospecificity in a contrastereoelectronically controlled pinacol rearrangement of alkoxycyclobutane derivatives. A novel route to vicinally substituted cyclopentanones

Article abstract of DOI:10.1021/jo00113a036

A four-step sequence for the synthesis of vicinally substituted cyclopentanones 5 and 9 has been developed starting from the acyclic ketones 1. The key step involves a storeospecific pinacol-type rearrangement of the cyclobutane ring embodied in oxabicycl