4H-1,2,4-pyridothiadiazine 1,1-dioxides and 2,3-dihydro-4H-1,2,4- pyridothiadiazine 1,1-dioxides chemically related to diazoxide and cyclothiazide as powerful positive allosteric modulators of (R/S)-2-amino-3- (3-hydroxy-5-methylisoxazol-4-yl)propionic ac

Article abstract of DOI:10.1021/jm970694v

A series of 4H-1,2,4-pyridothiadiazine 1,1-dioxides and 2,3-dihydro-4H- 1,2,4-pyridothiadiazine 1,1-dioxides bearing various alkyl and aryl substituents on the 2-, 3-, and 4-positions was synthesized and tested as possible positive allosteric modulators o