Novel potent and m2-selective antimuscarinic compounds which penetrate the blood-brain barrier

DOI: 10.1016/0223-5234(96)88210-9

Source and publish data:

European Journal of Medicinal Chemistry p. 61 - 70 (1995)

Update date:2022-08-03

Topics:

Authors:

Cohen, V. I.

Jin, B. Jin, B.

Gitler, M. S.

Cruz, R. A. de la

Boulay, S. F.

et al. et al.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0223-5234(96)88210-9

A series of 5-<<<(dialkylamino)alkyl>-1-phenyl>acetyl>-10,11-dihydro-5H-dibenzo<1,4>diazepin-11-ones 1 were prepared as potential m₂-selective ligands.The binding affinities and selectivities of these compounds for the muscarinic cholinerg

Full text of DOI:10.1016/0223-5234(96)88210-9

Products guided by the article

Product name:5-{2-[4-(5-Bromo-pentyl)-phenyl]-acetyl}-5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-one

Cas No:163400-04-2

R&D Labs maybe for 163400-04-2

Suzhou SuKaiLu Chemical Technology Co., Ltd.

Contact:+86-512-62766020

Address:Floor 4, Building 1, Xinyi Pharmaceutical Valley Wisdom Industrial Park, 415 Changyang Street, Suzhou Industrial Park, Jiangsu Province
Shanghai Bocimed Pharmaceutical Co., Ltd.

website:http://www.bocimed.com

Contact:+86-21-68861632

Address:Building 1, Lane 647, Songtao Road, Zhangjiang High-Tech Park, Shanghai
Hangzhou Hysen Pharma co.,Ltd.

website:http://www.hysenpharma.cn/

Contact:0086-571-88298791

Address:#701,Gudun Road Hangzhou
Jinan Hongfangde Pharmatech Co.LTD

Contact:0531-88870908

Address:F Bldg,750#,Shunhua Rd,New&High-tech Zone,Jinan,Shandong,China 250101
Beijing Harmony Chemical Co., Ltd.

Contact:86-010-84956928

Address:Room 207, Jin feng he B building, No 8 Xin Jie Kou Wai Street, Xi Cheng District, Beijing,PRC. 10008

Relevant to this article

Probing the Mechanism of Bioactivation of MPTP Type Analogs by Monoamine Oxidase B: Structure-Activity Studies on Substituted 4-Phenoxy-, 4-Phenyl-, and 4-Thiophenoxy-1-cyclopropyl-1,2,3,6-tetrahydropyridines

Doi:10.1021/tx00047a010
(1995)
A one-pot four-component synthesis of pyrrolo[1,2-a]quinolines

Doi:10.3184/174751914X14031091272010
(2014)
Synthesis of the dimethyl ester of 1-deoxy-L-idonojirimycin-1- methylenphosphonate: A new approach to iminosugar phosphonates

Doi:10.1080/07328300600731990
(2006)
Palladium-catalyzed addition of hexamethylditin to allenes

Doi:10.1021/om00086a036
(1984)
Structural features of n-acylcytisines

Doi:10.1007/s10600-010-9495-7
(2009)
The discovery of tetrahydrofluorenones as a new class of estrogen receptor β-subtype selective ligands

Doi:10.1016/j.bmcl.2006.03.098
(2006)

Article Doi