Horner-Wadsworth-Emmons olefination of nonstabilized phosphonates. A new synthetic approach to β,γ-unsaturated amides

Article abstract of DOI:10.1016/0040-4020(94)01046-3

Aminolysis of readily accessible β-diethoxyphosphonyl-γ-butyrolactones 5 and 22 provides a convenient entry to (E)-β,γ-unsaturated amides 8 and 24 respectively. The key step of the aminolysis involves elimination of diethoxyphosporic acid from the corresp